Computational Biologists Awards

Understanding how beneficial and harmful gut bacteria influence digestion, immunity, and the gut–brain axis Introduction The human gut is home to a vast and dynamic microbial ecosystem known as the gut microbiome . Composed primarily of bacteria, along with viruses, fungi, and archaea, this internal community plays a fundamental role in maintaining human health. Advances in microbiology and genomics have revealed that gut microbes are not passive inhabitants but active regulators of digestion, immunity, metabolism, and even brain function. Understanding the Gut Microbiome The gut microbiome consists of trillions of microorganisms residing mainly in the large intestine. These microbes collectively possess a genetic capacity far exceeding that of the human genome, enabling them to perform biochemical functions essential to survival. Each individual’s microbiome is shaped by genetics, diet, environment, lifestyle, and early-life exposure, making it as unique as a fingerprint. Fast Facts ...

 Biology is no longer confined to high-tech laboratories or research institutions. A growing movement known as DIY Biology , often linked with biohacking , is empowering individuals to explore life science using simple tools, curiosity, and creativity. From students and hobbyists to citizen scientists, DIY biology is transforming how people learn, experiment, and interact with science.. What Is DIY Biology? DIY Biology (Do-It-Yourself Biology) refers to biological experimentation and learning conducted outside traditional academic or industrial labs . Using affordable equipment and open-source knowledge, individuals can perform experiments such as DNA extraction, microscopy, fermentation, and microbial observation—often at home or in community labs. Understanding Biohacking Biohacking is a related concept that focuses on optimizing human biology using science, data, and self-experimentation. This may include tracking sleep cycles, improving nutrition, monitoring heart rate var...

  Most of us believe our genes decide everything about our health and life. But modern biology shows something surprising: your environment can control how your genes work . This idea is called epigenetics , and it explains how lifestyle, food, and experiences influence gene activity without changing DNA itself. What Is Epigenetics? Epigenetics refers to chemical modifications that regulate gene activity without altering the underlying DNA code. These modifications act like molecular switches, telling genes when to activate and when to stay silent. The three major epigenetic mechanisms are: DNA methylation – adds chemical tags to DNA to silence genes Histone modification – changes how tightly DNA is wrapped around proteins Non-coding RNAs – regulate how genes are translated into proteins Together, these processes determine how cells with identical DNA—like brain cells and muscle cells—behave so differently. How the Environment Controls Your Genes Your genes resp...

  Introduction Aging is no longer seen as an unstoppable process. Cutting-edge research in senolytics —drugs designed to remove senescent or “zombie” cells—is opening new possibilities to improve healthspan, reduce age-related diseases, and even slow biological aging. Senescent cells stop dividing but continue to release inflammatory molecules that damage surrounding tissues, contributing to chronic conditions like arthritis, cardiovascular disease, and neurodegeneration. What Are Senolytics? Senolytics are a class of compounds that selectively target and eliminate senescent cells . Unlike general anti-aging supplements, these drugs focus on the root causes of aging at the cellular level. By clearing harmful cells, the body can reduce inflammation, repair tissues more effectively, and restore cellular balance. How Do They Work? Senescent cells accumulate naturally as we age. They act like “zombie cells,” remaining alive but secreting molecules that harm nearby cells. Senolytic...

  How mRNA Works Inside Human Cells Messenger RNA (mRNA) technology became globally recognized during the COVID-19 pandemic, but its true potential extends far beyond vaccines. Today, mRNA is emerging as a powerful platform that could transform how diseases are treated, prevented, and managed in modern medicine. Rather than delivering drugs directly, mRNA therapies provide instructions that enable the body’s own cells to produce therapeutic proteins. This innovative approach represents a major shift in medical science. What Makes mRNA Different? mRNA is a natural molecule found in all living cells. It carries instructions from DNA to produce proteins essential for life. In medical applications, synthetic mRNA is designed to temporarily instruct cells to make specific proteins that can treat disease. Unlike gene editing, mRNA does not permanently change DNA, making it a safer and more flexible therapeutic option. mRNA in Cancer Treatment One of the most exciting developments ...