Novel Bioinspired Quercetin-Based Polymers for the Sustained Release of Donepezil in Alzheimer’s Disease Therapy

Alzheimer’s disease remains one of the most challenging neurodegenerative disorders, driving the need for smarter and more effective drug delivery strategies. In this study, researchers introduce novel bioinspired quercetin-based polymers designed for the sustained and controlled release of donepezil, a frontline Alzheimer’s medication.



Inspired by quercetin, a natural flavonoid known for its neuroprotective properties, the team developed a fluorescent, pH-responsive molecularly imprinted polymer (MIP) capable of selectively recognizing donepezil. The optimized polymer demonstrated superior drug-binding capacity compared to non-imprinted systems and showed a strong pH-dependent release, achieving nearly complete drug release at physiological pH.

Importantly, the polymer was found to be non-cytotoxic and successfully released donepezil in vitro, leading to effective acetylcholinesterase inhibition. This work highlights the promise of quercetin-derived smart polymers as advanced platforms for targeted and stimuli-responsive drug delivery in Alzheimer’s disease therapy.

#AlzheimersDisease#DrugDelivery#Quercetin#SmartPolymers#MolecularImprinting#BiomedicalResearch#Neurodegeneration#SustainedRelease#pHResponsive#Nanomedicine#Neuroprotective#FluorescentPolymer


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